I have friends who use weird (to me) "gender neutral"-type pronouns along the lines of "zie" and "zir" and so on. I am bound to say it grates on me a fair bit, when I read it, far more than the use of "she" does. Though the use of that does occasionally surprise (rather than irritate) when I see it in an academic text, or something.

As an aside, the shift from having he/him as "gender neutral" has occasionally caused me problems in middle Welsh; in some of the famous love poetry, they use "dyn" (man) to mean the girl they're writing the poem to, which causes me great confusion.

/this post brought to you by insomniac rambling inc.